Cardiac Autonomic Neuropathy in the Diabetic Patient: D...

Cardiac Autonomic Neuropathy in the Diabetic Patient: Does ^sup 123^I-MIBG Imaging Have a Role to Play in Early Diagnosis?

Cardiac Autonomic Neuropathy in the Diabetic Patient: Does ^sup 123^I-MIBG Imaging Have a Role to Play in Early Diagnosis?

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From: Journal of Nuclear Medicine Technology | Date: June 1, 2004| Author: Scott, Lynda A; Kench, Peter L | Copyright Society of Nuclear Medicine Jun 2004. Provided by ProQuest LLC.

Objectives: In diabetes, extended adrenergic receptor stimulation with hyperglycemia and insulin deficiency is associated with cardiac autonomic dysfunction. Clinically evident diabetic cardiac autonomic neuropathy (CAN) is associated with a poor prognosis. Research studies indicate that autonomic function tests, which are traditionally used to diagnose diabetic CAN, are less sensitive than ^sup 123^I-metaiodobenzylguanidine (MIBG) imaging, particularly in the early stages of the disease. This established imaging technique makes use of the noradrenaline analog MIBG, which is radiolabeled with ...

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